Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Investigates the enigmatic Native American figure, assessing critical battles attributed to his leadership within a context of the Great Sioux Wars, exploring the relationships between the Lakota Sioux and other tribes and analyzing the subjugation of North Plains Native Americans. Reprint.

The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.

Trial for fabricating and falsifying the balance sheet for the year, which was issued to the stockholders of the bank.

William J. Bordeaux was a bona-fide member of the Brule band of the Sioux tribe. His grandfather James Bordeaux was one of the early French fur traders who bravely carried on his trade and barter with the Sioux when the virgin prairies of the west were still an open frontier. A lineal descendent of Red Cormorant Woman (Húntkálutawin), his grandmother, he was well versed in his mother tongue. Being proficient in several dialects of the native language, he was able to converse with sage and grizzled old warriors and thus obtain information impossible for a white man to learn. His close union with his own tribe and daily conversations with them is an assurance that no doubtful, or transcribed evidence, will appear on these pages. In Bordeaux’s search for material for a history of his people, he spent considerable time traveling and talking to the oldest Indians on the different Sioux Indian Reservations. Through his research he stored up and accumulated a wealth of stories and legends, with awe inspiring fables and facts that would be valuable to story writers. These fragmentary myths and authentic facts connected with his people would have been lost without these writings. In his travels for the purpose of obtaining datum relative to the hostile activities by the different war chiefs, he found one warrior that stood out alone, excelling all other Sioux war braves, as to courage, and cunning, “Crazy Horse,” an Oglála Sioux.

Primarily known for his postwar exploits, most famously for his 1876 defeat at Little Big Horn, George Armstrong Custer led a formidable cavalry that became known as Custer's Wolverines. This volume presents the Civil War letters of one of those Wolverines, James H. Kidd.